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An­ge­bot 76 von 159 vom 07.08.2019, 09:28

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Cha­rité Uni­ver­si­täts­me­di­zin Ber­lin - Dept. of Expe­ri­men­tal Neu­ro­logy & Cha­rité-BIH Cen­trum für The­ra­pie­for­schung

PhD stu­dent

Work­ing field:

We are loo­king for a highly moti­va­ted and dedi­ca­ted PhD stu­dent in an EU H2020-fun­ded coope­ra­tion pro­ject bet­ween AG Mer­gen­tha­ler (Dept. of Expe­ri­men­tal Neu­ro­logy) and AG Sta­chel­scheid (Centre for The­ra­peu­tic Rese­arch) to inves­ti­gate mecha­nisms of cell death and cell sur­vi­val in human nerve cells in human stem cell-based 2D and 3D models of the brain.

In this pro­ject, you will:
  • use human indu­ced plu­ri­po­tent stem cells (hiPSC) for the genera­tion of 2D, 3D and orga­noid models of the brain
  • work with models of neu­ro­nal damage
  • per­form mul­ti­di­men­sio­nal micro­scopy, high con­tent micro­scopy and cor­re­spon­ding image / data ana­ly­sis.

Require­ments:

You have recently com­ple­ted your uni­ver­sity stu­dies in life sci­en­ces, pre­fer­a­bly with a focus on cell bio­logy. Know­ledge in dealing with pri­mary cells or stem cells is an advan­tage, but not a pre­re­qui­site. You have know­ledge of cell bio­lo­gi­cal, mole­cu­lar bio­lo­gi­cal and bio­che­mi­cal stan­dard tech­ni­ques. You are inte­rested and wil­ling to fami­lia­rize yours­elf with the methods of auto­ma­ted micro­scopy (high con­tent ana­ly­sis) and mul­ti­di­men­sio­nal image and data ana­ly­sis, as well as with basic rese­arch in the cli­ni­cal neu­ro­sci­en­ces. An inde­pen­dent way of working, exact docu­men­ta­tion of all work steps, wil­ling­ness to estab­lish new tech­ni­ques and to pre­pare data ana­ly­ses inde­pendently, as well as a very good know­ledge of Eng­lish are requi­red.

How to ap­ply:

Can­di­da­tes are expec­ted show a good level of inde­pen­dence. Exact docu­men­ta­tion of all work, moti­va­tion to estab­lish new tech­ni­ques, pre­pare data ana­ly­ses, pro­ject reports and manu­scripts inde­pendently, very good know­ledge of the Eng­lish lan­guage, and excel­lent com­pu­ter skills are expec­ted.

Please include a cover let­ter describ­ing your past rese­arch expe­ri­ence and poten­tial future rese­arch inte­rests.

Please send your app­li­ca­tion docu­ments by email in PDF for­mat. Con­tact details are avail­able in the ori­gi­nal job pos­ting.

Please con­sult and refer to the ori­gi­nal job descrip­tion when app­ly­ing: https://www.charite.de/service/stellenangebot/angebot/detailinfo/dm10319_wissenschaftlicher_mitarbeiterin/